7/30/2023 0 Comments Download d2 50 000 iuThe secondary goal was to explore the effect of the interventions on cytokine concentrations and respiratory health. In the present pilot study, the primary goal was to establish an efficient once-daily dosing strategy and to investigate the efficacy of D2 and D3 at increasing s25OHD concentrations. Most of the recommendations are consensus-based due to lack of knowledge on benefit–safety ratio. Because of its higher efficiency at increasing serum 25-hydroxyvitamin D (s25OHD), vitamin D3 (D3) is currently preferred over vitamin D2 (D2). The current recommendations for vitamin D supplementation in CF were designed with focus on bone health. 4, 5 In CF, vitamin D concentrations have been associated with lung function, 2, 6 annual number of pulmonary exacerbations 7 and with total serum IgG levels. 2, 3 In addition to its importance for bone health, vitamin D acts as a potent immune modulatory agent with complex effects. 1 Vitamin D insufficiency is common in CF despite vitamin D supplementation. In cystic fibrosis (CF), the major cause of morbidity and mortality is progressive lung disease driven by recurring acute airway infections and chronic bacterial lung colonization. Vitamin D supplementation may contribute to reduced inflammation and improved lung function in CF. Change in s25OHD was positively correlated with changes in the adult Quality-of-Life respiratory score at the end of supplementation ( P=0.006, r=0.90), and with changes in FEV1 ( P=0.042, r=0.62) and FVC ( P=0.036, r=0.63) at one month of washout. Patients provided vitamin D3 improved FVC at the end of the trial ( P<0.05). The combined group of vitamin D2 and D3 treated patients decreased plasma IL-8 ( P<0.05). To increase s25OHD, the mean daily dose of vitamin D2 and D3 had to be increased up to 156 IU, respectively. Three months of intervention were followed by two of washout ( NCT01321905). The starting dose of 5000 IU (<16 years old) or 7143 IU/day ( ⩾16 years old) was further individually adjusted. Sixteen CF patients were randomized to receive vitamin D2 or D3 or to serve as controls. We aimed to study the efficacy of vitamin D2 and D3 at increasing serum 25-hydroxyvitamin D (s25OHD) concentrations and their effect on respiratory health in cystic fibrosis. Vitamin D3 is currently preferred over D2. Vitamin D insufficiency in cystic fibrosis is common.
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